臺灣博碩士論文加值系統

鎂合金作為可降解性醫用金屬材料具有彈性係數與比重接近人體骨骼以及在人體內生物相容性佳等優點，研究上廣泛受到矚目並具有人體硬組織修復植入場合之應用潛力。然而鎂合金的高化學活性卻造成在生理環境溶液下容易被腐蝕，因而造成降解速率過快的問題，因此控制其降解速率是鎂合金作為生醫植入物應用的關鍵。本研究採用AZ91D鎂合金並透過表面處理將具有良好生物活性與引導骨生長能力之氟離子取代型氫氧基磷灰石(FHA)披覆於AZ91D鎂合金表面，藉以減緩其腐蝕速率更加以提升AZ91D鎂合金之生物相容性，並探討表面鍍層附著性之力學性質和微觀結構分析，表面處理方法為藉由水熱法在175°C壓力釜飽和蒸汽壓環境下反應2小時，合成摻雜F離子之FHA鍍層並被覆於AZ91D表面，接著在FHA鍍層表面以旋轉塗佈方式被覆聚己內酯(PCL)表面層，進行FHA鍍層孔隙與親疏水性之表面改質，製備PCL/FHA複合鍍層改善FHA鍍層在模擬體液(SBF)與培養基(DMEM)對多孔FHA鍍層之滲透腐蝕，獲得具理想耐蝕表面複合鍍層。本研究發現使用水熱合成法加熱於175ºC並持溫2小時下，可在AZ91D鎂合金表面合成出結晶性良好之FHA鍍層，從SEM觀察發現FHA鍍層表面是由許多針狀團聚組織及板片狀組織堆積而成有較多的孔洞，經潤濕角測試發現親水性能較好，而使用旋轉塗佈法將PCL均勻塗佈在試片表面的PCL/FHA複合鍍層能將孔洞有效填補使疏水性能提升，可有效的抵抗試片鍍層被測試液體的滲入，利用拉伸試驗及百格試驗得知PCL/FHA複合鍍層附著強度較FHA鍍層優異，再利用動電位極化曲線與浸泡實驗測試得知PCL/FHA複合鍍層可有效的減緩腐蝕速率。

As a biodegradable medical material in the body, the advantages of Mg alloy are mechanical properties close to human bone and good biocompatibility. Mg-based alloy is a medical metallic implant that has attracted attention and has been widely studied. However, the high chemical activity of Mg alloys limits the application because of their easily corrosion behaviors and excessive degradation rate in physiological environment solutions. Therefore, controlling the degradation rate is an important factor for the Mg-based alloys developed as the biomedical implants. The aim of present research is to reduce the corrosion rate of AZ91D Mg alloy through the surface treatment and study microstructure features as well as the mechanical properties of surface coating. The use of fluorohydroxyapatite (FHA) has good biological activity, biocompatibility and ability to guide bone formation. After hydrothermal synthesizing for 2 hours under the saturated vapor pressure environment of an autoclave at 175°C, the synthetic F-doped FHA coating is coated on the surface of the AZ91D alloy to improve the corrosion resistance of the substrate. Then the FHA coating is coated with polycaprolactone (PCL) on the FHA surface layer by spin coating process to improve the surface hydrophobicity to slow down the penetration of physiological solutions (SBF and DMEM) in the FHA coating to obtain an ideal surface composite coating. The surface microstructures of the FHA, PCL/FHA composite coatings are observed by a scanning electron microscope (SEM). The mechanical properties and adhesion of FHA and PCL/FHA composite coatings were tested by the grid test and tensile test. The wetting contact angle were measured to analyze the hydrophilicity and hydrophobicity of the coatings with the simulated liquid. The potentiodynamic polarization curves and the immersion experiments were to evaluate the corrosion characteristics including the corrosion resistance of the material surface, and compare the electrochemical and the immersion resistance of AZ91D, FHA coating and PCL/FHA composite coating.=

摘要......i
Abstract......ii
誌謝......iv
目錄......v
表目錄......vii
圖目錄......viii
第一章 緒 論......1
第二章 文獻回顧......2
2-1 生醫材料......2
2-1-1 金屬材料......2
2-1-2 陶瓷材料......3
2-1-3 高分子材料......3
2-2 生物可降解性鎂合金與表面處理......4
2-2-1 鎂合金抗腐蝕改質處理......5
2-2-2 生物活性氟離子取代型氫氧基磷灰石......5
2-3 水熱法......6
2-4 動電位極化法原理[59]......6
第三章 實驗內容與方法......11
3-1 鎂合金基材前處理......11
3-2 水熱合成FHA鍍層......11
3-3 FHA鍍層旋轉塗佈PCL表面處理......12
3-4 X-ray 相組成分析......12
3-5 SEM微觀組織分析......12
3-6 表面親疏水性測試......13
3-7 鍍層附著力強度測量......13
3-7-1 百格測試......13
3-7-2 拉伸試驗......13
3-8 電化學抗腐蝕及浸泡試驗......14
3-8-1 配製SBF模擬體液與DMEM培養基溶液......14
3-8-2 動電位極化曲線分析(Potentiodynamic polarization curves)......14
3-8-3 浸泡實驗(Immersion tests)......15
第四章 實驗結果與討論......25
4-1 AZ91D、FHA鍍層、PCL/FHA複合鍍層觀察與分析......25
4-1-1 鍍層形貌......25
4-1-2 鍍層表面微觀組織分析......25
4-2 表面親疏水性測試......25
4-3 鍍層附著力強度測量......26
4-3-1 百格測試......26
4-3-2 拉伸試驗......26
4-4 X-ray 相組成分析......26
4-5 電化學抗腐蝕測試......27
4-5-1 在SBF模擬體液之動電位極化曲線分析......27
4-5-2 在DMEM培養基之動電位極化曲線分析......27
4-6 浸泡試驗......28
4-6-1 SBF模擬體液浸泡實驗......28
4-6-2 DMEM培養基浸泡實驗......29
第五章 結論......56
參考文獻......57

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