臺灣博碩士論文加值系統

在本研究中，我們展示了 U 形光纖傳感器對葡萄糖和氯化汞 (HgCl2) 的不同分辨率的靈敏度。 我們還介紹了使用 CO2 激光器以聚甲基丙烯酸甲酯 (PMMA) 為材料製造微流控系統的過程。 經過三個循環的實驗中不同濃度的葡萄糖和氯化汞的感測。 結果表明，隨著葡萄糖濃度從5%增加到50%，諧振波長和傳輸損耗均呈相同趨勢，最高波長靈敏度係數達到0.114，R2=0.95，最高傳輸靈敏度為0.09，R2 =0.94。 根據檢測氯化汞的經驗，最佳波長靈敏度為0.01，R2=0.43；最高透射靈敏度為0.0072，R2=0.785。 採用熱處理技術製造的U型光纖傳感器顯示出對葡萄糖的靈敏度高於對氯化汞的靈敏度。
最終，我們成功製作了深度為0.3毫米、寬度為0.2毫米的微流控系統。 通過混合葡萄糖 0% 和 50%，結果表明最終混合液體達到 25%，從而得出微流體系統正常工作的結論。

In this study, we demonstrate the sensitivity of U-shaped Optical Fiber Sensor with the different resolutions of Glucose and Mercury Chloride (HgCl2). We also indicate the process of fabricating a Microfluidics system by using CO2 laser with Poly Methyl Methacrylate (PMMA) as material. After three cycles of sensing the different concentrations of Glucose and HgCl2 in the experiments. It shows that resonance wavelength and transmission loss share the same trend when they both raise with the increase of Glucose Concentration from 5% to 50% with the highest wavelength sensitivity coefficient reach to 0.114 and R2=0.95 and the highest transmission sensitivity is 0.09 with R2=0.94. In the experience of sensing Mercury Chloride, the best wavelength sensitivity is 0.01 with R2=0.43 and the highest transmission sensitivity is 0.0072 with R2=0.785. There for the U-shaped Optical Fiber Sensor manufacturing with heat treatment technique shows the higher sensitivity with Glucose than that of Mercury Chloride.
Finally, we manufacture successfully the Microfluidics system with the dimensions including depth: 0.3 mm and width: 0.2 mm. By mixing Glucose 0% and 50%, the result indicates that final mixing liquid attains 25% leading to the conclusion that the Microfluidics system works appropriately.

ABSTRACT 3
ACKNOWLEDGEMENT 4
TABLE OF CONTENT 5
Chapter 1: Introduction 9
1.1 Preface 9
1.2 Literature Review 10
1.2.1 The methods of manufacturing U-Shaped Optical Fiber Sensor 10
1.2.2 The methods of manufacturing Microfluidics channel 14
1.2.3 Methods of sensing Glucose 17
1.2.4 Methods of sensing Mercury Chloride 21
1.3 Researching purpose 23
Chapter 2: Basic Theories 23
2.1 Fundamental knowledge of the Propagation of Light 23
2.2 U-shaped Optical Fiber Theory 25
2.3 Microfluidics Fundamental theories. 29
Chapter 3: Research Methodology 31
3.1 Optical Fiber Sensor Manufacture process- U-Shape Sensor 31
3.1.1 Equipment and material required for the process: 31
3.1.2 U-Shaped Optical fiber sensor fabrication steps: 32
3.2 Microfluidics Channel Design, Simulation and Fabrication Process 34
3.2.1 Software, equipment and material for manufacturing microfluidics channel: 34
3.2.2 The steps of Fabricating Microfluidics channel 35
3.2.3 Method of Directly writing of CO2 laser on the PMMA surface 38
3.2.4 Method of Ultrasonic welding 40
3.2.4 A Method of Thermal Pressing 43
3.2.5 Using PDMS molding for fabricating the Microfluidics channels 43
3.3 Mixing liquid using for the Lab-on-a-chip system 45
3.3.1 Equipment and material: 45
Chapter 4: Results and Discussions 46
4.1 The U-shaped optical fiber sensor after heating fabrication 46
4.2 COMSOL simulation 48
4.3 Results of each fabrication method for microchannels 51
4.3.1 Directly writing using CO2 laser 51
4.3.2 Using Ultrasonic welding to assemble the Microfluidics System 57
4.3.3 Using Thermal Pressing to assemble the Microfluidics System 59
4.3.4 Using PDMS molding for fabricating the microchannels 61
4.4 Mixing results of Microfluidics System 62
4.5 The sensitivity of U-shaped sensor with the different concentrations of Glucose 67
4.6 The sensitivity of U-shaped sensor with the different concentrations of HgCl2 76
Chapter 5: Conclusion and future work 87
5.1 Conclusions 87
5.2 Future work 87

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