臺灣博碩士論文加值系統

本研究提出使用雷射加工製程來製作傾斜式布拉格光纖光柵 ( Tilted fiber Bragg gratings；TFBG ) 感測器，應用於生醫、乙醇及環境重金屬檢測實驗。其中TFBG感測器的感測原理是光透射過纖芯與纖殼模態之間的相互耦合模態來產生對應頻譜飄移，纖芯模態有量測應力及溫度變化的能力；纖殼模態具有量測外界折射率變化的能力。
第一部分是生醫檢測實驗，在TFBG感測器的纖殼表層上製作出三明治結構感測層來進行胃泌激素( Gastrin-17 )之抗原、抗體濃度檢測；第二部份是乙醇檢測實驗，在TFBG感測器的表層上塗覆液晶進行乙醇濃度量測實驗，透過塗覆不同厚度的感測層來分析其靈敏度；第三部份是環境重金屬檢測實驗，在TFBG感測器的表層分別塗覆3HP-C3COOC2-SR3及3HP-C3COOCA-SR3進行汞離子濃度檢測，透過不同濃度的汞離子來分析感測器可以檢測到的最低濃度及靈敏度比較。
生醫實驗結果顯示，感測器在抗體濃度4 μg/ml、抗原濃度20 μg/ml時，靈敏度為最佳，傳輸損耗平均靈敏度可達0.014 dB/min，並且有SPR的現象產生；而在乙醇實驗結果中，發現液晶塗覆的厚度將會跟靈敏度有關，厚度約1 μm時的傳輸損耗靈敏度為未塗覆之感測器的6倍，靈敏度為-0.006 dB/%；最後在環境重金屬汞離子的量測結果中，發現兩種溶液量測汞的靈敏度接近，靈敏為0.004 dB/ppm，本感測器低濃度1 ppm即可被檢測到，在檢測環境重金屬濃度上是一大幫助。
實驗證明本感測器可透過在表面塗覆不同感測層，來進行各項不同的液體檢測，未來可開發將不同結構之感測層製作在感測器表層，以量測不同物之理量，成為新型感測器。

In this study, a laser process is proposed to produce tilted fiber Bragg gratings (TFBG) for bio-medical, ethanol and environmental heavy metal detection experiments. The TFBG sensor is based on the principle that light is transmitted through the mutually coupled modes of the fiber core and the fiber cladd to produce a corresponding spectral shift, with the core mode capable of measuring stress and temperature variations and the cladd mode capable of measuring external refractive index variations.
The first part is bio-medical experiment, a sandwich structured sensing layer is fabricated on the surface of the TFBG sensor to measure the concentration of Gastrin-17 antigen and antibodies; the second part is ethanol detection experiment, the surface of the TFBG sensor is coated with liquid crystal(LC) to measure the concentration of ethanol and its sensitivity is analyzed by coated the different thicknesses sensing layer. The third part of the experiment is about environmental heavy metal detection, 3HP-C3COOC2-SR3 and 3HP-C3COOCA-SR3 were respectivelycoated on the surface of the TFBG sensor to measure the mercury ions concentration, and the minimum mercury ions concentration could be detected by the sensing analysed, wchich is detection different concentrations of mercury ions and the sensitivity was compared.
The results of the bio-medical experiment showed that the best sensitivity of the sensor was when the concentration of the antibody was 4 μg/ml and the concentration of the antigen was 20 μg/ml, and the average sensitivity of the transmission loss was 0.014 dB/min, and a phenomenon of SPR was observed. In the ethanol experiment, it was found that the liquid crystal coated thickness would be related to the sensitivity, the transmission loss sensitivity at 1 μm thickness was 6 times higher than the uncoated sensor, the sensitivity could be reached at -0.006 dB/%. Finally, in the results of the environmental heavy metal mercury ion experiment, it was found that the sensitivity of the two solutions was almost the same, the sensitivity was near 0.004 dB/ppm. The sensor can detect 1 ppm low concentration of heavy metal mercury ion, which is a good help for the detection of environmental heavy metal concentrations.
By experiment has been proven that TFBG sensor can be used to detect different liquids by coating with different sensing layers on the TFBG sensor surface. In the future, a new type of TFBG sensor can be developed to measure the physical quantity of different substances by applying different structures of sensing layers to the TFBG sensor surface.

致謝
摘要
ABSTRACT
目錄
圖目錄
表目錄
第一章 序論
1.1 研究動機
1.2 文獻回顧
1.2.1布拉格光纖光柵之製作方法
1.2.2 傾斜式布拉格光纖光柵感測器直徑對靈敏度之影響
1.2.3 傾斜式布拉格光纖光柵感測器塗覆金對折射率之影響
1.2.4 傾斜式布拉格光纖光柵感測器塗覆液晶對折射率之影響
1.2.5 光纖感測器應用於生醫感測
1.2.6 光纖感測器應用於環境重金屬感測
1.3 研究目的
第二章 基礎理論
2.1光纖光柵基本原理
2.2 耦合模態理論分析
2.3 傾斜光纖光柵之共振波長位置
2.4 傾斜光纖光柵外界折射率靈敏度分析
第三章 研究方法與步驟
3.1 光纖製程－傾斜式布拉格光纖光柵感測器製程
3.2 光纖製程－掃描傾斜式布拉格光纖光柵製程
3.3 蝕刻製程－光纖濕蝕刻製程
3.4 塗覆製程－奈米金( Nanogold )
3.5 塗覆製程－3-Mercaptopropionic acid（3MPA）
3.6 塗覆製程－液晶( Liquid Crystal )
3.6.1 液晶配置
3.6.2 感測端塗覆液晶製程步驟
3.6.3 球型端塗覆液晶製程步驟
3.7 實驗架構－傾斜式布拉格光纖光柵應用於生醫檢測
3.8 實驗架構－傾斜式布拉格光纖光柵塗覆液晶應用於乙醇量測
3.8.1 傾斜式布拉格光纖光柵塗覆液晶測量乙醇實驗
3.8.2 球型傾斜式布拉格光纖光柵塗覆液晶測量乙醇實驗
3.9 實驗架構－環境重金屬汞離子濃度感測
3.9.1 傾斜式布拉格光纖光柵塗覆3HP- C3COOC2-SR3及3HP-C3COOCA-SR3
3.9.2 傾斜式布拉格光纖光柵塗覆3HP- C3COOC2-SR3量測汞離子濃度
3.9.3 傾斜式布拉格光纖光柵塗覆 3HP-C3COOCA-SR3量測汞離子濃度
第四章 實驗結果與討論
4.1 傾斜式布拉格光纖光柵不同直徑比較
4.2 傾斜式布拉格光纖光柵應用於生醫檢測
4.2.1 傾斜式布拉格光纖光柵應用於生醫檢測－固定抗原改變抗體
4.2.2 傾斜式布拉格光纖光柵應用於生醫檢測－固定抗體改變抗原
4.2.3 傾斜式布拉格光纖光柵應用於生醫檢測－微共振腔SPR效應
4.3 傾斜式布拉格光纖光柵塗覆液晶應用於乙醇量測
4.3.1 傾斜式布拉格光纖光柵應用於乙醇量測－濃度0% - 100%
4.3.2 傾斜式布拉格光纖光柵塗覆液晶應用於乙醇量測－濃度0% - 100%
4.3.3 傾斜式布拉格光纖光柵應用於乙醇量測－濃度0% - 10%
4.3.4 傾斜式布拉格光纖光柵塗覆液晶應用於乙醇量測－濃度0% - 10%
4.4 反射球型傾斜式布拉格光纖光柵塗覆液晶應用於乙醇量測
4.4.1 球型傾斜式布拉格光纖光柵應用於乙醇量測－濃度0% - 100%
4.4.2 球型傾斜式布拉格光纖光柵有塗覆液晶應用於乙醇量測－濃度0% - 100%
4.5 傾斜式布拉格光纖光柵應用於環境重金屬汞濃度檢測
4.5.1 傾斜式布拉格光纖光柵塗覆3HP- C3COOC2-SR3應用於汞離子濃度檢測－濃度0 ppm - 100 ppm
4.5.2 傾斜式布拉格光纖光柵塗覆3HP-C3COOCA-SR3應用於汞離子濃度檢測－濃度0 ppm – 100 ppm
4.5.3 傾斜式布拉格光纖光柵塗覆3HP-C3COOC2-SR3應用於汞離子濃度檢測－濃度0 ppm – 5 ppm
4.5.4 傾斜式布拉格光纖光柵塗覆3HP-C3COOCA-SR3應用於汞離子濃度檢測－濃度0 ppm – 5 ppm
第五章 結論
第六章 未來展望
6.1 扭轉型傾斜式布拉格光纖光柵感測器
6.2 新型空芯光纖結合傾斜式布拉格光纖光柵感測器
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