臺灣博碩士論文加值系統

由於馬兜鈴屬植物中所含的馬兜鈴酸成分會造成使用者產生急性腎功能衰竭現象，因此對於藥材中馬兜鈴酸成分的定量更顯得重要。在本論文中，建立了利用1H-NMR做為分析儀器，分析定量中藥材中所含馬兜鈴酸I及II的含量。定量方法採用質子吸收訊號的相對積分面積與化學位移在8.45ppm的內標準品蒽做比較，偵測極限為0.0107 mg/mL。NMR光譜法具有快速分析及簡單操作的優點，但靈敏度卻不如HPLC靈敏，在本論文中也利用HPLC來確認實驗的結果。
第二部份則是利用HPLC搭配UV偵測器，發展出對樟芝子實體中三萜類及單苯環類的定量分析方法。當中首次建立的9種三萜類及4種單苯環類的HPLC指紋圖譜也被應用在區分野生樟芝及人工培養樟芝的差別，除此之外，此定量分析方法也可對野生樟芝及人工培養樟芝的三萜類及單苯環類成分做定量。

The determination and quantification of aristolochic acids I and II, which will cause acute renal failure, in the plants of the genus Aristolochia is important. In the present study, a quantitative determination of aristolochic acids I and II in plants using 1H NMR spectroscopy was reported. The quantification was performed by relative integration of two proton singlets resonating at δ 8.45 of anthracene. The detection limit was determined to be 0.0107 mg/mL. The 1H NMR spectroscopy is a fast analytical method and relatively easy to perform, but lack the sensitivity that can be achieved with HPLC. Thus, the accuracy of this method was ensured by HPLC.
The second part is a method, which was developed for quantitative determination of triterpene acids and benzenoids from the fruiting body of Taiwanofungus camphorates, based on HPLC with UV detector. The HPLC fingerprint of the nine triterpene acids and four benzenoids were developed for the first time and applied to distinguish the wild and cultured species of T. camphoratus. Furthermore, the quantifications of triterpene acids and benzenoids were accomplishment for the wild and cultured species.

Abstrsct………………III
摘要……………IV
誌謝……………V
表目錄…………VIII
圖目錄……………………IX
第一部份………1
第一章 緒論…………3
第二章 文獻回顧……………………4
第一節 馬兜鈴的使用……………………………4
第二節 馬兜鈴植物的介紹……………6
第三節 馬兜鈴酸藥理活性……………………7
第四節 馬兜鈴酸分析方法回顧…………………12
FDA concerned about botanical products, containing aristolochic acid…………………..17
第三章 研究目的……………………………18
第四章 研究方法……………………………………………20
第一節 實驗使用儀器及藥品…………………………………20
第二節 馬兜鈴酸(Aristolochic acid)提取方式…………21
第三節 1H-NMR操作條件……………22
第四節 HPLC操作條件……………………23
第五章 結果與討論………………………………24
第一節 馬兜鈴酸抽取與1H-NMR分析馬兜鈴酸訊號………24
第二節 馬兜鈴酸之檢量線………………………25
第三節 1H-NMR偵測馬兜鈴酸之偵測極限……………31
第四節 以1H-NMR定量馬兜鈴酸之含量…………………36
第六章 結論…………………………………………43
第二部份………………………………44
第一章 緒論…………………………………………………46
第二章 文獻回顧…………………………47
第一節 牛樟芝的使用…………………………47
第二節 牛樟芝的介紹………………………………48
第三節 牛樟芝的化學成分…………………………………50
第四節 牛樟芝的藥理活性………………………………52
第三章 研究方法………………………………58
第一節 實驗使用儀器及藥品………………………58
第二節 HPLC操作條件……………………………………59
第三節 牛樟芝純化合物分類…………………………60
第四章 結果與討論…………………………62
第一節 各化合物之檢量線及再線性…………………………62
第二節 HPLC偵測各化合物之偵測極限(LOD)及定量極限(LOQ).71
第三節 各化合物之回收率……………………72
第四節 樟芝初萃物之成分分析…………………………73
第五章 結論…………………………………80
附錄一……………81
附錄二………………………………………………82
參考文獻1…………………………………………100
參考文獻2……………………………………………110

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