1.陳啟楨、蘇慶華、藍明煌 (2001)。樟芝固體栽培及其生物活性之研究。菌類科學16(1-2)。
65-72。
2.吳彩平 (2006)以固態發酵製備樟芝米及其品質與抗氧化性質。國立中興大學碩士論文。3.陳盈宜、張慧欣、李曉媛、許輔 (2008)。餵食樟芝子實體對於小鼠體內肝腫瘤細胞之免疫調節
與抑制腫瘤效果之探討。台灣農業化學與食品科學46(2), 87-95。
4.毛正倫(2009)。食藥用菇及其固態發酵保健食品之開發。食品生技 2009， NO.18：50-55。
5.張東柱 (2009)。牛樟與牛樟芝的恩怨情仇。科學人雜誌，2009，88：112-3。
6.陳淑德、黃琮祐(2013)。世界最貴的真菌-牛樟芝。國立宜蘭大學農業推廣委員會農業推廣(季
刊)。通訊總號第063號。
7.蘇慶華(2013)。台灣特有國寶牛樟芝。科學研習，2013年7月，No.52-7：8-17。
8.社團法人臺灣食藥用菇菌類生技協會，臺灣牛樟菇菌產業聯盟作(2014)。台灣特有藥用菇牛樟
芝(菇) 的正確學名。社團法人臺灣食藥用菇菌類生技協會。臺北市。
9. Aebi H. (1984) Catalase in vitro. Methods Enzymol 105:121–6. PMID: 6727660.
10. Ao, Z.H., Xu, Z.H., Lu, Z.M., Xu, H.Y., Zhang, X.M., Dou, W.F. (2009). Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases. J Ethnopharmacol 121, 194-212. doi: 10.1016/j.jep.2008.10.039 PMID: 19061947.
11.Baraona, E., Lieber, C.S. (1979). Effects of ethanol on lipid metabolism. J Lipid Res 20, 289-315.
12.Bataller R, Brenner DA. (2005). Liver fibrosis. J Clin Invest 115:209–18. PMID: 15690074.
13.Bode C, Bode JC. (1997). Alcohol absorption, metabolism, and production in the gas-trintestinal tract. Alcohol Health Res World, 21:82–83.
14.Camps J, Bargallo T, Gimenez A, Alie S, Caballeria J, Pares A, et al. (1992). Relationship between hepatic lipid peroxidation and fibrogenesis in carbon tetrachloride-treated rats: effect of zinc administration. Clin Sci (Lond). 83(6):695–700.
15.Cepeda V, Fuertes MA, Castilla J, Alonso C, Quevedo C, Pérez JM (2007) : Biochemical mechanisms of cisplatin cytotoxicity. Anticancer Agents Med Chem, 7:3–18.
16.Charels K, Klöppel G. (1991). Pathology and pathogenesis of toxic (alcoholic) liver dis-ease. Hepatogastroenterology 38:189–194.
17.Chen CC, Shiao YJ, Lin RD, Shao YY, Lai MN, Lin CC, et al. (2006). Neuroprotective diterpenes from the fruiting body of Antrodia camphorata. J Nat Prod 69(4):689–91. PMID: 16643055
18.Chen SC, Lu MK, Cheng JJ, Wang DL. (2005). Antiangiogenic activities of polysaccha-rides isolated from medicinal fungi. FEMS Microbiol Lett, 249:247–254.
19.Chen X, Ying X, Zhang W, Chen Y, Shi C, Hou Y, Zhang Y. (2013). The hepatoprotec-tive effect of fraxetin on carbon tetrachloride induced hepatic fibrosis by antioxidative activities in rats. Int Immunopharmacol 17(3):543–7. doi: 10.1016/j.intimp.2013.08.006 PMID: 23994349
20.15. Chen YC, Liu YL, Li FY, Chang CI, Wang SY, Lee KY, et al. (2011). Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids. Acta Pharmacol Sin. 32(7):904–11. doi:10.1038/aps.2011.36 PMID: 21602840
21.16. Chen YS, Pan JH, Chiang BH, Lu FJ, Sheen LY. (2008). Ethanolic extracts of An-trodia cinnamomea mycelia fermented at varied times and scales have differential effects on hepatoma cells and normal primary hepatocytes. J Food Sci 73:H179–H185.
22.17. Cheng JJ, Huang NK, Chang TT, Wang DL, Lu MK. (2005). Study for an-ti-angiogenic activities of polysaccharides isolated from Antrodia cinnamomea in endo-thelial cells. Life Sci, 76:3029–3042.
23.18. Chiang PC, Lin SC, Pan SL, Kuo CH, Tsai IL, Kuo MT, Wen WC, Chen P, Guh JH. (2010). Antroquinonol displays anticancer potential against human hepatocellular carci-noma cells: a crucial role of AMPK and mTOR pathways. Biochem Pharmacol 79:162–171.
24.Cronholm, T., Jones, A.W., Skagerberg, S. (1988). Mechanism and regulation of ethanol elimination in humans: intermolecular hydrogen transfer and oxidoreduction in vivo. Alcohol Clin Exp Res 12, 683-686.
25.Dai YY, Chuang CH, Tsai CC, Sio HM, Huang SC, Chen JC, Hu ML. (2003). The pro-liferation of Anthrodia camphorate against acute hepatotoxicity of alcohol in rat. J Food Drug Ann, 11:177–185.
26.Day, C.P., Yeaman, S.J. (1994). The biochemistry of alcohol-induced fatty liver. Biochim Biophys Acta 1215, 33-48.
27.Deng JS, Huang SS, Lin TH, Lee MM, Kuo CC, Sung PJ, et al. (2013). Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice. J Agric Food Chem. 61(21):5064–71. doi: 10.1021/jf303820k PMID: 23495748
28.Dhiman RK, Chawla YK. (2005). Herbal medicines for liver diseases. Dig Dis Sci.; 50(10):1807–12. PMID: 16187178
29.Du YC, Chang FR, Wu TY, Hsu YM, El-Shazly M, Chen CF, et al. (2012). Antileuke-mia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models. Phytomedicine. 19(8–9):788–96. doi: 10.1016/j.phymed.2012.03.014 PMID: 22516893
30.Farazi PA, DePinho RA. (2006). Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Canc 6:674–687.
31.Friedman, S.L. (1997). Molecular mechanisms of hepatic fibrosis and principles of ther-apy. J Gastroenterol 32, 424-430.
32.Galli, A., Pinaire, J., Fischer, M., Dorris, R., Crabb, D.W. (2001). The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanolinduced fatty liver. J Biol Chem 276, 68-75.
33.Gao, B., Bataller, R. (2011). Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141, 1572-1585.
34.Garbuzenko DV. (2015). Contemporary concepts of the medical therapy of portal hyper-tension under liver cirrhosis.World J Gastroenterol 21(20):6117–26. doi: 10.3748/wjg.v21.i20.6117 PMID: 26034348
35.Geethangili M, Tzeng YM. (2011). Review of pharmacological effects of Antrodia camphorata and its bioactive compounds. Evid Based Complement Alternat Med.; 2011:212641. doi: 10.1093/ecam/nep108 PMID: 19687189
36.Geng Y, Wang J, Sun Q, Xie M, Lu ZM, Xu HY, et al. (2015). Identification of antrodin B from Antrodia camphorata as a new anti-hepatofibrotic compound using a rapid cell screening method and biological evaluation. Hepatol Res. 2015 Mar 9. doi: 10.1111/hepr.12516 [Epub ahead of print]
37.Gokila Vani M, Kumar KJ, Liao JW, Chien SC, Mau JL, et al. (2013). Antcin C from Antrodia cinnamomea protects liver cells against free radical-induced oxidative stress and apoptosis in vitro and in vivo through Nrf2-dependent mechanism. Evid Based Complement Alternat Med. 2013:296082. doi: 10.1155/ 2013/296082 PMID: 24391672
38.Gomaa AI, Khan SA, Toledano MB, Waked SD. (2008). Taylor-Robinson, hepatocellu-lar carcinoma: epidemiology, risk factors and pathogenesis. World J Gastroenterol, 14:4300–4308.
39.Hall PM, Plummer JL, Ilsley AH, Ahern MJ, Cmielewski PL, Williams RA. (1994). The pathology of liver injury induced by the chronic administration of alcohol and 'low-dose' carbon tetrachloride in Porton rats. J Gastroenterol Hepatol. 9(3):250–6. PMID: 8054523
40.Han HF, Nakamura N, Zuo F, Hirakawa A, Yokozawa T, Hattori M. (2006). Protective effects of a neutral polysaccharide isolated from the mycelium of Antrodia cinnamomea on Propionibacterium acnes and lipopolysaccharide induced hepatic injury in mice. Chem Pharm Bull (Tokyo). 54(4):496–500.
41.Hemmann, S., Graf, J., Roderfeld, M., Roeb, E. (2007). Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies. J Hepatol 46, 955-975.
42.Hoekstra, L.T., de Graaf, W., Nibourg, G.A., Heger, M., Bennink, R.J., Stieger, B., van Gulik, T.M. (2012). Physiological and biochemical basis of clinical liver function tests: A Review. Ann Surg. doi:10.1097/SLA.0b013e31825d5d47
43.Horiguchi, N., Wang, L., Mukhopadhyay, P., Park, O., Jeong, W.I., Lafdil, F., Osei-Hyiaman, D., Moh, A., Fu, X.Y., Pacher, P., Kunos, G., Gao, B. (2008). Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 134, 1148-1158.
44.Hseu, Y.C., Chen, S.C., Yech, Y.J., Wang, L., & Yang, H.L. (2008). Antioxidant activity of Antrodia camphorataon free radical-induced endothelial cell damage. Journal of Ethnopharmacology, 118(2), 237-245.
45.Hsiao G, Shen MY, Lin KH, Lan MH, Wu LY, Chou DS, et al. (2003). Antioxidative and hepatoprotective effects of Antrodia camphorata extract. J Agric Food Chem. 51(11):3302–8. PMID: 12744658
46.Hsieh YC, Rao YK, Wu CC, Huang CY, Geethangili M, Hsu SL, Tzeng YM. (2010). Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway. Chem Res Toxicol, 23:1256–1267.
47.Hsieh YC, Rao YK, Whang-Peng J, Huang CY, Shyue SK, Hsu SL, et al. (2011). Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway. J Agric Food Chem. 59(20):10943–54. doi: 10.1021/jf202771d PMID: 21916504
48.Hsu YL, Kuo YC, Kuo PL, Ng LT, Kuo YH, Lin CC (2005): Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines. Canc Lett, 221:77–89.
49.Hsu, Y.L., Kuo, P.L., Cho, C.Y., Ni, W.C., Tzeng, T.F., Ng, L.T., Kuo, Y.H, Lin, C.C. (2007). Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor κB pathway. Food and Chemical Toxicology, 45(7), 1249-1257.
50.Huang, C.H., Chang, C.C., Lin, C.M., Wang, S.T., Wu, M.T., Li, E.I.C., Chang, H.C. & Lin, C.C. (2010a). Promoting effect of Antrodia camphorataas an immunomodulating adjuvant on antitumor efficacy of HER-2/neu DNA vaccine. Cancer Immunology, Im-munotherapy, 59(8), 1259-1272.
51.Huang, C.H., Chang, Y.Y., Liu, C.W., Kang, W.Y., Lin, Y.L., Chang, H.C., Chen, Y.C. (2010b). Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage. J Agric Food Chem 58(6), 3859-66. doi: 10.1021/jf100530c PMID: 20192205
52.Huang GJ, Deng JS, Huang SS, Lee CY, Hou WC, Wang SY, et al. (2013). Hepatopro-tective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury. Food Chem. 141(3):3020–7. doi: 10.1016/j.foodchem.2013.03.061 PMID: 23871054
53.Huang GJ, Deng JS, Chen CC, Huang CJ, Sung PJ, Huang SS, Kuo, Y.H. (2014). Meth-anol extract of Antrodia camphorata protects against lipopolysaccharide-induced acute lung injury by suppressing NF-κB and MAPK pathways in mice. J Agric Food Chem. 62(23):5321–9. doi: 10.1021/jf405113g PMID:24849405
54.Huang RL, Huang QL, Chen CF, Chang TT, Chou CJ. (2003). Anti-viral effects of ac-tive compounds from Antrodia camphorata on wild-type and lamivudine-resistant mu-tant HBV. Chin Pharmaceut J, 55:371–379.
55.Huang YL, Chu YL, Ho CT, Chung JG, Lai CI, Su YC, et al. (2015). Antcin K, an active triterpenoid from the fruiting bodies of basswood-cultivated Antrodia cinnamomea, inhibits metastasis via suppression of integrin-mediated adhesion, migration, and invasion in human hepatoma cells. J Agric Food Chem.; 63 (18):4561–9. doi: 10.1021/jf5059304 PMID: 25911944
56.Idilman R, De Maria N, Colantoni A, Van Thiel DH. (1998). Pathogenesis of hepatitis B and C-induced hepatocellular carcinoma. J Viral Hepat, 5:285–299.
57.Jacobs BP, Dennehy C, Ramirez G, Sapp J, Lawrence VA. (2002). Milk thistle for the treatment of liver disease: a systematic review and meta-analysis. Am J Med. 113(6):506–15. PMID: 12427501
58.Jeong, W.I., Park, O., Gao, B. (2008). Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gas-troenterology 134, 248-258
59.Jiménez-López, J.M., Carrasco, M.P., Segovia, J.L., Marco, C. (2002). Resistance of HepG2 cells against the adverse effects of ethanol related to neutral lipid and phospho-lipid metabolism. Biochem Pharmacol 63, 1485-1490.
60.Jordan P, Carmo-Fonseca M (2000): Molecular mechanisms involved in cisplatin cyto-toxicity. Cell Mol Life Sci, 57:1229–1235.
61.Knittel, T., Mehde, M., Grundmann, A., Saile, B., Scharf, J.G., Ramadori, G. (2000). Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat. Histochem Cell Biol 113, 443-453.
62.Kumar, K.J., Chu, F.H., Hsieh, H.W., Liao, J.W., Li, W.H., Lin, J.C., Shaw, J.F., Wang, S.Y. (2011). Antroquinonol from ethanolic extract of mycelium of Antrodia Cinamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation. J Ethnopharmacol 136, 168-177. doi: 10.1016/j.jep.2011.04.030 PMID: 21540101
63.Kuo PL, Hsu YL, Cho CY, Ng LT, Kuo YH, Lin CC. (2006). Apoptotic effects of An-trodia cinnamomea fruiting bodies extract are mediated through calcium and cal-pain-dependent pathways in Hep 3B cells. Food Chem Toxicol, 44:1316–1326.
64.Kuo YH, Lin CH, Shih CC. (2015a). Ergostatrien-3β-ol from Antrodia camphorata in-hibits diabetes and hyperlipidemia in high-fat-diet treated mice via regulation of hepatic related genes, glucose transporter 4, and AMP-activated protein kinase phosphorylation. J Agric Food Chem. 63(9):2479–89. doi: 10.1021/acs.jafc.5b00073 PMID: 25693659
65.Kuo YH, Lin CH, Shih CC. (2015b). Antidiabetic and antihyperlipidemic properties of a triterpenoid compound, dehydroeburicoic acid, from Antrodia camphorata in vitro and in streptozotocin-induced mice. J Agric Food Chem. 63(46):10140–51. doi: 10.1021/acs.jafc.5b04400 PMID: 26503742
66.Lee IH, Huang RL, Chen CT, Chen HC, Hsu WC, Lu MK. (2002). Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects. FEMS Microbiol Lett. 209(1):63–7. PMID: 12007655
67.Lee TH, Lee CK, Tsou WL, Liu SY, Kuo MT, Wen WC. (2007). A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorate. Planta Med 73:1412–1415.
68.Lee WT, Lee TH, Cheng CH, Chen KC, Chen YC, Lin CW. (2015). Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1-and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions. Food Chem Toxicol. 78:33–41. doi:10.1016/j.fct.2015.01.012 PMID: 25656647
69.Lettéron P, Labbe G, Degott C, Berson A, Fromenty B, Delaforge M, et al. (1990). Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an in-hibitor of metabolic activation and as a chain-breaking antioxidant. Biochem Pharmacol. 39(12):2027–34. PMID: 2353942
70.Liaw CC, Chen YC, Huang GJ, Tsai YC, Chien SC, Wu JH, et al. (2013). An-ti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata. J Nat Prod. 76(4):489–94. doi: 10.1021/ np300443p PMID: 23517145
71.Lieber CS. (1991). Alcohol, liver, and nutrition. J Am Coll Nutr , 10:602–632..
72.Lien HM, Lin HW, Wang YJ, Chen LC, Yang DY, Lai YY, et al. (2011). Inhibition of anchorage-independent proliferation and G0/G1 cell-cycle regulation in human colorectal carcinoma cells by 4,7-dimethoxy-5-methyl-l,3-benzodioxole isolated from the fruiting body of Antrodia camphorate. Evid Based Complement Alternat Med. 984027. doi: 10.1093/ecam/nep020 PMID: 19293251
73.Lien HM, Tseng CJ, Huang CL, Lin YT, Chen CC, Lai YY. (2014). Antimicrobial activ-ity of Antrodia camphorata extracts against oral bacteria. PLoS One. 9(8):e105286. doi: 10.1371/journal.pone.0105286 PMID: 25144619
74.Lin, E.S., Yang, C.T., Chou, H.J. & Chang, T.T. (2010). Screening of antioxidant ativeties by the edible basidiomyceteAntrodia cinnamomeastrains in submerged culture. Journal of Food Biochemistry, 34(6), 1141-1156.
75.Lin WC, Kuo SC, Lin WL, Fang HL, Wang BC. (2006). Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol, 12:2369–2374.
76.Lin YW, Chiang BH. (2011). 4-acetylantroquinonol B isolated from Antrodia cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels. J Agric Food Chem, 59:8625–8631.
77.Lin YW, Pan JH, Liu RH, Kuo YH, Sheen LY, Chiang BH. (2010). The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells. J Sci Food Agric, 90:1739–1744.
78.Liu KJ, Leu SJ, Su CH, Chiang BL, Chen YL, Lee YL. (2010). Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced T helper type 2 responses in a mouse model of asthma. Immunology. 129(3):351–62. doi: 10.1111/j.1365-2567. 2009.03175.x PMID: 19909376
79.Liu, D.Z., Liang, H.J., Chen, C.H., Su, C.H., Lee, T.H., Huang, C.T., Hou, W.C., Lin, S.Y., Zhong, W.B., Lin, P.J., Hung, L.F. & Liang, Y.C. (2007). Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and soidstate culture of Taiwanofungus camphoratusin microglia and the mechanism of its action. Journal of Ethnopharmacology, 113(1), 45-53
80.Liu D.Z, Liang Y.C, Lin S.Y, Lin Y.S, Wu W.C, Hou W.C, et al. (2007). Antihypertensive activities of a solid-state culture of Taiwanofungus camphoratus (Chang-chih) in spontaneously hypertensive rats. Biosci Biotechnol Biochem. 71(1):23–30. PMID: 17213674
81.Liu, J.J., Huang, T.S., Hsu, M.L., Chen, C.C., Lin, W.S., Lu, F.J. & Chang, W.H. (2004). Antitumor effects of the partially purified polysaccharides from Antrodia camphorataand the mechanism of its action. Toxicology and Applied Pharmacology, 201(2), 186-193.
82.Liu, K.J, Leu SJ, Su CH, Chiang BL, Chen YL, Lee YL. (2009). Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced T helper type 2 responses in a mouse model of asthma. Immunology. 129(3):351–62. doi: 10.1111/j.1365-2567. 2009.03175.x PMID: 19909376
83.Liu Y.W, Lu KH, Ho CT, Sheen L.Y. (2012). Protective effects of Antrodia cinnamomea against liver injury. J Tradit Complement Med. 2(4):284–94. PMID: 24716143
84.Lu MK, Cheng JJ, Lai WL, Lin YR, Huang NK. (2006). Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A(2A) receptors. Life Sci. 79(3):252–8. PMID: 16443241
85.Lu MK, Cheng JJ, Lai WL, Lin YJ, Huang NK. (2008). Fermented Antrodia cin-namomea extract protects rat PC12 cells from serum deprivation-induced apoptosis: the role of the MAPK family. J Agric Food Chem. 56(3):865–74. doi: 10.1021/jf072828b PMID: 18186605
86.Luper S. (1998). A review of plants used in the treatment of liver disease: part 1. Altern Med Rev. 3 (6):410–21. PMID: 9855566
87.Lu Z.M, Tao WY, Zou XL, Fu HZ, Ao ZH. (2007). Protective effects of mycelia of An-trodia camphorata and Armillariella tabescens in submerged culture against etha-nol-induced hepatic toxicity in rats. J Ethnopharmacol. 110(1):160–4. PMID: 17092673
88.Lu, Z.M., Tao, W.Y., Xu, H.Y., Ao, Z.H.., Zhang, X.M., Xu, Z.H. (2011). Further stud-ies on the hepatoprotective effect of Antrodia camphorata in submerged culture on etha-nol-induced acute liver injury in rats. Nat Prod Res 25, 684-695. doi: 10.1080/14786410802525487 PMID: 20623423
89.McCay PB, Lai EK, Poyer JL, DuBose CM, Janzen EG. (1984). Oxygen- and car-bon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro. J Biol Chem. 259(4):2135–43. PMID: 6321461
90.Meng LM, Pai MH, Liu JJ, Yeh SL. (2012). Polysaccharides from extracts of Antrodia camphorata mycelia and fruiting bodies modulate inflammatory mediator expression in mice with polymicrobial sepsis. Nutrition. 28(9):942–9. doi: 10.1016/j.nut.2012.01.006 PMID: 22541057
91.Moradpour D, Blum HE. (2005). Pathogenesis of hepatocellular carcinoma. Eur J Gas-troenterol Hepatol 17:477–483.
92.Muir AJ. (2015). Understanding the complexities of cirrhosis. Clin Ther. pii: S0149-2918(15)00846-2.
93.Muriel P, Moreno MG, Hernández Mdel C, Chávez E, Alcantar LK. (2005). Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treat-ment: effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid. Basic Clin Pharmacol Toxicol. 96(5):375–80. PMID: 15853930
94.Palmes D, Spiegel HU. (2004). Animal models of liver regeneration. Biomaterials. 25(9):1601–11. PMID: 14697862
95.Park DK, Lim YH, Park HJ. (2013a). Antrodia camphorata grown on germinated brown rice inhib its HT-29 human colon carcinoma proliferation through inducing G0/G1 phase arrest and apoptosis by targeting the β-catenin signaling. J Med Food. 16(8):681–91. doi: 10.1089/jmf.2012.2605 PMID:23957353
96.Park DK, Park HJ. (2013b). Ethanol extract of Antrodia camphorata grown on germinated brown rice suppresses inflammatory responses in mice with acute DSS-induced colitis. Evid Based Complement Alternat Med. 2013b; 2013:914524.
97.Paulová J, Dvorák M, Kolouch F, Vánová L, Janecková L. (1990). Verification of the hepatoprotective and therapeutic effect of silymarin in experimental liver injury with tetrachloromethane in dogs. Vet Med (Praha). 35(10):629–35.
98.Phuong do T, Ma CM, Hattori M, Jin JS. (2009). Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease.
99.Phytother Res 23:582–584.Popper H, Thung SN, Gerber MA. (1981). Pathology of alcoholic liver diseases. Semin Liver Dis, 1:203–216.
100.Popper H, Thung SN, Gerber MA. (1981). Pathology of alcoholic liver diseases. Semin Liver Dis, 1:203–216.
101.Reagan-Shaw S, Nihal M, Ahmad N. (2008). Dose translation from animal to human studies revisited. FASEB J. 22(3):659–61. PMID: 17942826
102.Schaff Z, Székely E, Járay B, Kiss A. (2004). Pathology of liver tumors. Orv Hetil, 145:368–374.
103.Song, T.Y. & Yen, G.C. (2002). Antioxidant properties of Antrodia camphoratain submerged culture. Journal of Agricultural and Food Chemistry, 50(11), 3322-3327.
104.Song, T.Y. & Yen, G.C (2003). Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats. J Agric Food Chem, 51(6):1571–7. PMID: 12617586
105.Song TY, Hsu SL, Yen GC (2005a) : Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture. J Ethnopharmacol , 100:158–167.
106.Song TY, Hsu SL, Yeh CT, Yen GC (2005b) : Mycelia from Antrodia camphorata in Submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway. J Agric Food Chem, 53:5559–5564.
107.Sturgill MG, Lambert GH. (1997). Xenobiotic-induced hepatotoxicity: mechanisms of liver injury and methods of monitoring hepatic function. Clin Chem. 43(8 Pt 2):1512–26. PMID: 9265903
108.Surveillance and response: WHO. Hepatitis B, Department of communable diseases. 2002.
109.Tipoe, G.L., Leung, T.M., Liong, E.C., Lau, T.Y., Fung, M.L., Nanji, A.A. (2010). Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice. Toxicology 273, 45-52.
110.Toyoki Y, Sasaki M, Narumi S, Yoshihara S, Morita T, Konn M. (1998). Semiquantitative evaluation of hepatic fibrosis by measuring tissue hydroxyproline. Hepatogastroenterology 45(24):2261–4. PMID: 9951907
111.Tsai, M.C., Song, T.Y., Shih, P.H. & Yen, G.C. (2007). Antioxidant properties of water-soluble polysaccharides from Antrodia cinnamomeain submerged culture. Food Chemistry, 104(3), 1115-1122.
112.Tsai PY, Ka SM, Chang JM, Lai JH, Dai MS, Jheng HL, Kuo MT, Chen P, Chen A. (2012). Antroquinonol differentially modulates Tcell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine acceleratedsevere lupus nephritis. Arthritis Rheum, 64(1):232–42.doi: 10.1002/art.33328 PMID: 21905011
113.Tsai PY, Ka SM, Chao TK, Chang JM, Lin SH, Li CY, Kuo MT, Chen P, Chen A. (2011). Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice. Free Radic Biol Med, 50(11):1503–16. doi: 10.1016/j.freeradbiomed.2011.02.029 PMID: 21376112
114.Tsai TC, Tung YT, Kuo YH, Liao JW, Tsai HC, Chong KY, Chen CM. (2015). An-ti-inflammatory effects of Antrodia camphorata, a herbal medicine, in a mouse skin is-chemia model. J Ethnopharmacol, 159:113–21. doi: 10.1016/j.jep.2014.11.015 PMID: 25449461
115.Tu, S.H., Wu, C.H., Chen, L.C., Huang, C.S., Chang, H.W., Chang, C.H., Lien, H.M. & Ho, Y.S. (2012). In vivo antitumor effects of 4,7-dimethoxy-5-methyl-1,3-benzodioxole isolated from the fruiting body of Antrodia camphorata through activation of the p53-mediated p27/Kip1 signaling pathway.Journal of Agricultural and Food Chemistry, 60(14), 3612-3618.
116.Wang LC, Kuo IU, Tsai TY, Lee CL. ( 2013). Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fi-brosis. Appl Microbiol Biotechnol.; 97(23):9955–67. doi: 10.1007/s00253-013-5214-1 PMID: 24061418
117.Wang SC, Lee TH, Hsu CH, Chang YJ, Chang MS, Wang YC, Ho YS, Wen WC, Lin RK. (2014). Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential. J Agric Food Chem, 62(24):5625–35. doi: 10.1021/jf4056924 PMID: 24784321
118.Wong CM. (2008). Ng IO: Molecular pathogenesis of hepatocellular carcinoma. Liver Int, 28:160–174.
119.Wong, F.W., Chan, W.Y., Lee, S.S. (1998). Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression. Toxicol Appl Pharmacol 153, 109-118.
120.Wu, M.F., Peng, F.C., Chen, Y.L., Lee, C.S., Yang, Y.Y., Yeh, M.Y., Liu, C.M., Chang, J.B., Wu, R.S., Yu, C.C., Lu, H.F., Chung, J.G. (2011). Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test. In Vivo 25, 419-423.
121.Wu MT, Tzang BS, Chang YY, Chiu CH, Kang WY, Huang CH, et al. (2011). Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol. J Agric Food Chem. 59(8):4248–54. doi: 10.1021/jf104561h PMID: 21401100
122.Wu SH, Ryvarden L, Chang TT. (1997). Antrodia camphorate (‘niu-chang-chih’), new combination of a medicinal fungus in Taiwan. Botanical Bulletin of Academia Sinica. 38(4):273–5.
123.Xia E, Rao G, Van Remmen H, Heydari AR, Richardson A. (1995). Activities of antioxidant enzymes in various tissues of male Fischer 344 rats are altered by food restriction. J Nutr. 125(2):195–201. PMID: 7861246
124.Xiao, J., Liong, E.C., Ching, Y.P., Chang, R.C., So, K.F., Fung, M.L., Tipoe, G.L. (2012). Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation. J Ethnopharmacol 139, 462-470.
125.Yang CM, Zhou YJ, Wang RJ, Hu ML. (2009). Anti-angiogenic effects and mechanisms of polysaccharides from Antrodia cinnamomea with different molecular weights. J Ethnopharmacol, 123:407–412.
126.Yang PY, Hu DN, Liu FS. (2013). Cytotoxic effect and induction of apoptosis in human cervical cancer cells by Antrodia camphorata. Am J Chin Med. 41(5):1169–80. doi: 10.1142/S0192415X13500791 PMID: 24117076
127.Yang SM, Ka SM, Hua KF, Wu TH, Chuang YP, Lin YW, et al. (2013). Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome. Free Radic Biol Med. 61:285–97. doi: 10.1016/j.freeradbiomed. 2013.03.024 PMID: 23567192
128.Yeh CT, Huang WC, Rao YK, Ye M, Lee WH, Wang LS, et al. (2013). A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells. Carcinogenesis. 34(12):2918–28. doi: 10.1093/carcin/bgt255 PMID: 23880305
129.Yeh CT, Rao YK, Yao CJ, Yeh CF, Li CH, Chuang SE, et al. (2009). Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells. Cancer Lett. 285(1):73–9. doi: 10.1016/j.canlet.2009.05.002 PMID: 19477064
130.You, M., Liang, X., Ajmo, J.M., Ness, G.C. (2008). Involvement of mammalian sirtuin 1 in the action of ethanol in the liver. Am J Physiol Gastrointest Liver Physiol 294, G892-898.
131.You, M., Matsumoto, M., Pacold, C.M., Cho, W.K., Crabb, D.W. (2004). The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127, 1798-1808
132.You, M., Rogers, C.Q. (2009). Adiponectin: a key adipokine in alcoholic fatty liver. Exp Biol Med (Maywood) 234, 850-859.
133.Yue PY, Wong YY, Wong KY, Tsoi YK, Leung KS. ( 2013). Current evidence for the hepatopro tective activities of the medicinal mushroom Antrodia cinnamomea. Chin Med. 8(1):21. doi: 10.1186/1749-8546-8-21 PMID: 2418054976.
134.Zakhari S. (2006). Overview: How is alcohol metabolized by the body? Alcohol Res Health, 29:245–254.