臺灣博碩士論文加值系統

玉米赤黴烯酮是一種具有特殊毒性的生物毒素。它具有類雌激素作用，能造成動物流產、死胎、發情等生殖機能異常，也可能導致生長下降、免疫抑制、不育、畸形等病徵。這種黴菌毒素主要通過影響動物的生殖性能、而引起細胞凋亡、致畸、損傷DNA、氧化損害、影響免疫機能等機制，來影響動物與人類的健康。本研究收集來亞洲地區穀物及飼料(越南、中國、菲律賓、泰國、日本、馬來西亞、台灣、韓國)，共計八國，本研究檢驗穀物及飼料中玉米赤黴稀酮黴菌毒素所含之濃度，在2009年八月至2010年八月間，檢驗數量共計612件。檢測結果顯示各地區的檢出率(ZON毒素濃度大於0.1 ppm所佔比例)，越南地區樣本為80 %、台灣地區樣本為38 %、馬來西亞地區樣本為20 %、泰國地區樣本為7 %、菲律賓地區樣本為35 %、韓國地區樣本為47 %、 日本地區樣本為53 %、中國地區樣本為59 %。這些數據顯示，此毒素的檢出值得重視，以降低動物與人類之健康風險。

Zearalenone is a special biological toxin that has estrogen-like effects. The toxin can cause animals’ miscarriage, stillbirth, abnormal reproductive function, decreased growth, immune suppression, infertility, and malformations. The toxin affects the reproductive performance by influencing the body, causing apoptosis, teratogenicity, DNA damage, oxidative damage, immune function and other mechanisms to affect animal and human health. This research collected grains and animal feeds from areas in Asia (a total of eight countries: Vietnam, China, Philippines, Thailand, Japan, Malaysia, Taiwan, South Korea), and performed analyses for zearalenone content. Total number of tests was 612. Test results showed the detection rates of these regions were: Vietnam 80%, Taiwan 38%, Malaysia 20%, Thailand 7%, Philippines 35%, Korea 47 %, Japan 53 % and China 59%. These statistics revealed the importance of monitoring this mycotoxin for reducing the health risks for animals and human.

封面內頁
博、碩士論文授權書
論文口試委員會審定書(中文版)
論文口試委員會審定書(英文版)

中文摘要 I
Abstract II
誌 謝 III
目錄 IV
表目錄 VII
圖目錄 VIII
第一章、前言 1
第二章、文獻回顧 2
2-1 Zearalenone理化性質 2
2-2 Zearalenone對人體之影響 5
2-3 Zearalenone對反芻動物之影響： 5
2-4 Zearalenone對牛隻之影響: 6
2-5 Zearalenone對羊隻之影響: 8
2-6 Zearalenone對豬隻之影響: 9
2-7 ZON的毒性 11
2-7-1 Zearalenone的毒性機制 11
2-7-2 Zearalenone對生殖毒性之影響 12
2-7-3 Zearalenone對肝臟毒性之影響 13
2-7-4 Zearalenone對免疫抑制之影響 14
2-7-5 Zearalenone對DNA和染色體之影響 14
2-8 Zearalenone之脫毒處理 15
2-8-1物理脫毒法 16
2-8-2化學脫毒法 16
2-8-3酶解法 16
2-8-4吸附法 17
2-8-5生物去毒法 17
2-9 Zearalenone之毒素殘留 18
2-9-1殘留於組織: 18
2-9-2殘留於乳汁: 18
2-9-5殘留於雞蛋: 19
2-10 ZON的檢測方法 19
2-10-1高效液相色譜法( HPLC法) 20
2-10-2高效液相色譜-質譜聯用法(HPLC-MS) 20
2-10-3毛細管電泳法(CE法) 21
2-10-4免疫學檢測法 22
2-10-5免疫親合層析法(IC法) 22
2-10-6酶聯免疫吸附法(ELISA法) 23
2-11 zearalenone在全球各國之汙染情形 29
第三章、亞洲各國地區玉米赤黴稀酮毒素檢測調查與統計 34
3-1 實驗器材與藥品 51
3-1-1器材 52
3-1-2藥品配製 53
3-1-3實驗步驟： 54
3-2 螢光判讀機校正步驟 55
3-3各國zearalenone毒素含量檢測結果 56
3-4亞洲各國ZON毒素檢測數據 60
第四章、結論 68
參考文獻 69

表目錄
表 1、食品中玉米赤黴稀酮最大允許含量 24
表 2、食品中玉米赤黴稀酮最大允許含量 25
表 3、食品和飼料在不同國家最高含量限制 26
表 4、ZON急性毒性(半致死劑量)在不同的動物模組中 28
表 5、全球食品及飼料ZON毒素含量(一) 29
表 6、全球食品及飼料ZON毒素含量(二) 31
表 7、受檢樣品（中國） 34
表 8、受檢樣品（日本） 37
表 9、受檢樣品（韓國） 38
表 10、受檢樣品（馬來西亞） 40
表 11、受檢樣品（菲律賓） 41
表 12、受檢樣品（泰國） 42
表 13、受檢樣品（台灣） 48
表 14、受檢樣品（越南） 50



圖目錄
圖 1、玉米赤黴烯酮毒素（Zearalenone）之雌激素之類似物化學結構圖 4
圖 2、亞洲各國國家ZON檢測最高毒素含量 57
圖 3、亞洲各國國家平均ZON毒素含量 58
圖 4、亞洲各國國家ZON毒素檢出率 59
圖 5、台灣區ZON毒素檢測含量百分比 60
圖 6、越南區ZON毒素檢測含量百分比 61
圖 7、馬來西亞區ZON毒素檢測含量百分比 62
圖 8、泰國區ZON毒素檢測含量百分比 63
圖 9、菲律賓區ZON毒素檢測含量百分比 64
圖 10、韓國區ZON毒素檢測含量百分比 65
圖 11、日本區ZON毒素檢測含量百分比 66
圖 12、中國區ZON毒素檢測含量百分比 67

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