鎂合金彈性模數與人體的皮質骨相當接近，加上具有生物相容性，可作為生醫取代硬組織用途，因鎂合金的活性大，在生理環境下不耐腐蝕，所以要做為生醫植入材料使用，控制鎂合金的降解速率是很重要的關鍵。由於生物活性陶瓷之氫氧基磷灰石(HA)具有良好的生物活性、生物相容性及引導骨生成能力，本研究利用水熱法合成添加了Sr及F元素於氫氧基磷灰石(HA)結構進行離子部分取代而將HA改質為Sr/F部分取代型氫氧基磷灰石(SrFHA)鍍層，探討並比較披覆於在AZ91鎂合金表面之Mg(OH)2、FHA、SrHA、SrFHA鍍層和披覆在純鎂金屬表面之FHA鍍層改善抗腐蝕性之效果。本實驗使用X光繞射儀分析鍍層相組成成分、利用SEM觀察各不同鍍層之表面微觀組織差異、以高解析電子微探儀(EPMA)分析鍍層之元素分佈，電化學腐蝕分析則使用動電位極化曲線及開路電位對各鍍層之抗腐蝕能力進行比較，利用百格試驗測試鍍層附著力強度並比較鍍層貼附性，藉由模擬體液浸泡實驗檢測鎂合金基材經不同生物活性鍍層被覆後，在長時間浸泡期間模擬體液之pH值變化、試片重量損失以及腐蝕速率。

Mg-based alloys are generally used as implants for the hard tissue replacement in biomedical application because of their excellent biocompatibility and low elastic modulus close to the human cortical bones. Mg alloys have high activity in nature, and they display low corrosion resistance in physiological environments. Therefore, it is important to control the degradation rate of Mg alloys for the further biomedical applications. Since bioactive hydroxyapatite (HA) ceramic represents excellent bioactivity, biocompatibility and osteoconductivity, hydrothermal synthesizing process is adopted in the present study to synthesize partially Sr or F ions doped HA (SrHA, FHA) and Sr/F co-substituted HA (SrFHA) coatings on pure Mg and Mg alloy substrate. The purpose of this study is to compare the effect of anti-corrosion resistance of Mg alloys with the deposition of Mg(OH)2, FHA, SrHA and SrFHA coatings. The phase composition of Mg(OH)2, FHA, SrHA and SrFHA coatings is analyzed by X-ray diffractometer (XRD). Surface microstructural features of hydrothermal coatings are observed by scanning electron microscope (SEM), and the distribution of surface elements are analyzed by EPMA. The adhesion between Mg(OH)2, FHA, SrHA, SrFHA coatings and Mg alloy substrates are tested by the standard adhesive tests. The comparison for electrochemical corrosion performances of various hydrothermally-coated Mg alloys are examined by the potentiodynamic polarization curves. In addition, long-term immersion tests of hydrothermally-coated Mg alloys are performed to evaluate the variation of pH values, weight loss percentage and corrosion rate of specimens within the simulated body fluid.

摘要........................... i
Abstract....................... iii
誌謝........................... v
目錄........................... vi
表目錄.......................... viii
圖目錄.......................... ix
第一章 緒 論................................................ 1
第二章 文獻回顧................................................ 3
2-1 生醫材料 [1]............................................ 3
2-1-1 陶瓷材料................................................ 3
2-1-2 金屬材料................................................ 4
2-1-3 高分子材料.............................................. 4
2-2 生物可降解鎂合金........................................ 5
2-2-1 促進鎂合金抗腐蝕之改質處理............................... 5
2-2-2 生物活性陶瓷表面鍍層..................................... 6
2-3 水熱法(Hydrothermal synthesis).......................... 7
2-4 鎂合金於生理環境電化學特性............................... 8
2-5 電化學腐蝕原理.......................................... 9
2-5-1 動電位極化曲線(potentiodynamic polarization curve)...... 9
第三章 實驗方法與步驟.......................................... 13
3-1 鎂合金基材前處理........................................ 13
3-2 水熱合成Mg(OH)2、FHA、SrHA及SrFHA鍍層.................... 13
3-3 微觀結構與相組成分析..................................... 14
3-3-1 X-ray相組成分析......................................... 14
3-3-2 SEM微觀組織分析......................................... 14
3-3-3 場發射高解析電子微探儀(EPMA)............................. 14
3-3-4 化學分析電子光譜分析(ESCA)............................... 14
3-4 鍍層附著力強度測量....................................... 15
3-5 表面粗糙度量測(Surface roughness)....................... 15
3-6 動電位極化曲線測試(electrochemical tests)................ 15
3-7 模擬體液浸泡實驗(immersion tests)....................... 16
第四章 結果與討論.............................................. 25
4-1 水熱合成SrFHA鍍層與各鍍層相組成分析與表面形貌觀察.......... 25
4-1-1 XRD相成分組成分析....................................... 25
4-1-2 表面微觀組織分析........................................ 25
4-1-3 XPS化學鍵結分析......................................... 26
4-1-4 EPMA定性分析............................................ 27
4-2 鍍層附著力測試.......................................... 27
4-3 試片鍍層表面粗糙度測試................................... 28
4-4 鍍層動電位極化曲線分析................................... 28
4-5 模擬體液浸泡分析........................................ 29
第五章 結論................................................... 74
參考文獻........................................................ 75
Extended Abstract.............................................. 85

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