臺灣博碩士論文加值系統

生物可降解性鎂基合金是相當受矚目的輕量化生醫金屬材料，其彈性模數、生物相容性與人體的皮質骨相當接近，可作為體內可降解之生醫植入材料。由於鎂合金活性大，在生理環境溶液下容易腐蝕，因此控制鎂合金的降解速率是發展鎂合金作為生醫材料的關鍵。氫氧基磷灰石(HA)生物活性陶瓷具有良好生物相容性、生物活性、引導骨生成能力，本研究基於鎂合金表面被覆具保護性之鍍層可有效減緩鎂合金腐蝕速率的概念下，藉由水熱法在175ºC、在壓力釜飽和蒸汽壓環境下反應2小時，合成Mg(OH)2鍍層，另以HA結構為基礎，合成摻雜Sr2+離子之SrHA鍍層與F–離子之FHA鍍層被覆於AZ91鎂合金表面。為了進一步對水熱法陶瓷鍍層表面進行化學鍵結之改性與電化學效應之探討，再於Mg(OH)2、SrHA、FHA鍍層表面接枝單分子鍍膜，利用X光繞射分析並比較鍍層相組成、XPS分析探討表面化學鍵結狀態、以SEM觀察微觀組織特性、表面欽輸水性測試、並在細胞培養液環境比較披覆單分子鍍膜後之Mg(OH)2、SrHA、FHA鍍層與未披覆單分子鍍層之抗腐蝕性。

Biodegradable Mg-based alloys are state-of-art light-weight biometallic materials. The elastic modulus of Mg alloy is close to the human cortical bone, and Mg alloys can be used as biodegradable hard tissue implants for the biological applications. However, the application of Mg alloys is restricted because of their high activity and low corrosion resistance within physiological environments. Thus, to control the degradation rate is a key point to develop Mg-based alloys used as the biological materials. Bioactive ceramic hydroxyapatite (HA) has excellent biocompatibility, bioactivity and osteoconductivity. On the basis of a concept for reducing the corrosion rate of Mg alloys can be achieved through the deposition of protective surface coatings, surface Mg(OH)2, SrHA and FHA coatings are synthesized and deposited on AZ91 Mg alloy by the175ºC hydrothermal treatment in a saturated steam pressure environment held for 2 h. In order to evaluate the effect of surface chemistry and bonding modification on improving the electrochemical behaviors of hydrothermal bioactive ceramic coatings, self-assembled monolayers are further deposited on Mg(OH)2, SrHA and FHA coatings. The phase composition of hydrothermal coatings is analyzed by X-ray diffractometer. The surface chemical bonding states are detected by XPS analysis. The variation of surface morphologies and wettability between Mg(OH)2, SrHA and FHA coatings are observed by SEM. In addition, the electrochemical corrosion behaviors of hydrothermal synthesized and monolayers deposited Mg(OH)2, SrHA and FHA surface coatings are evaluated in the Dulbecco's modified eagle medium (DMEM) solution.

摘要 ....i
Abstract ....ii
誌謝 ....iv
目錄 ....v
表目錄 ....vii
圖目錄 ....viii
第一章 緒 論 ....1
第二章 文獻回顧 ....3
2-1 生醫材料 ....3
2-1-1 金屬材料 ....3
2-1-2 陶瓷材料 ....4
2-1-3 高分子材料 ....5
2-2 生物可降解性鎂合金與表面處理 ....5
2-2-1 鎂合金表面改質處理 ....6
2-2-2 生物活性氫氧基磷灰石 ....7
2-3 水熱法 ....7
2-4 單分子鍍層 ....8
2-4-1 表面親疏水性[89-90] ....8
2-5 電化學原理 ....10
2-5-1 動電位極化曲線(potentiodynamic polarization curve) ....10
第三章 實驗方法與步驟 ....15
3-1 鎂合金基材前處理 ....15
3-2 水熱合成Mg(OH)2、HA及不同含量之SrHA鍍層 ....15
3-3 表面單分子鍍層化學改性接枝處理 ....16
3-4 X-ray相組成分析 ....16
3-5 SEM微觀組織分析 ....16
3-6 表面親疏水性測試(Surface wettability) ....17
3-7 化學分析電子光譜分析(Electron Spectroscopy for Chemical Analysis, ESCA) ....17
3-8 鍍層附著力強度測量 ....17
3-9 動電位極化曲線分析(Polarization curves) ....17
3-10 模擬體液浸泡實驗(Immersion tests) ....18
第四章 結果與討論 ....24
4-1 AZ91基材、水熱合成SrHA鍍層及鍍層相組成分析與表面形貌觀察 ....24
4-2 表面微觀組織分析 ....24
4-3 XPS化學鍵結分析 ....25
4-4 表面潤濕性測試 ....26
4-5 鍍層附著性測試 ....26
4-6 鍍層之耐腐蝕性研究 ....26
4-6-1 試片在SBF中動電位極化曲線分析結果與討論 ....26
4-6-2 試片在DMEM中動電位極化曲線分析結果與討論 ....27
4-7 鍍層之模擬體液浸泡實驗 ....28
第五章 結論 ....48
參考文獻 ....49

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